FAU Brain Institute
Henriette van Praag, Ph.D.

 

Our Research

The van Praag lab aims to understand the beneficial effects of exercise on brain function and behavior. In particular, we focus on the running-induced increase in new neurons in the adult rodent dentate gyrus of the hippocampus, a brain area that is essential for learning and memory. In mice, voluntary wheel running more than doubles the production of new neurons in the dentate gyrus, in association with enhanced synaptic plasticity and memory function.

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Henriette van Praag

PRINCIPAL INVESTIGATOR

Henriette van Praag

Henriette van Praag received her Ph.D. from Tel-Aviv University (Israel). She obtained postdoctoral training at Robert Wood Johnson Medical School, NJ, followed by a position as a staff scientist at the Salk Institute for Biological Studies in La Jolla, CA. Dr. van Praag started her own research group at the National Institute on Aging in Baltimore in 2007. She moved her laboratory to Florida Atlantic University in 2018. She is an Associate Professor of Biomedical Sciences at the Charles E. Schmidt College of Medicine and FAU Brain Institute, and serves as co-Editor-in-Chief for the journal Brain Plasticity.


 
 

Lab Members


Etay Aloni
  • Etay Aloni, Ph.D., Postdoctoral Fellow
    ealoni@fau.edu

    Publications:
    Aloni E, Ruggiero A, Gross A. Segal M. Learning deficits in adult Mitochondria Carrier Homolog 2 forebrain knockout mouse. Neuroscience 2018 DOI: https://doi.org/10.1016/j.neuroscience.2018.10.035
    Ruggiero A, Aloni E, Korkotian E, Zaltsman Y, Oni-Biton E, Kuperman Y, Tsoory M, Shachnai L, Levin-Zaidman S, Brenner O, Segal M, Gross A. Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions. Sci Rep. 2017 DOI: 10.1038/srep44401
    Aloni E, Shapira M, Eldar-Finkelman H, Barnea A. GSK-3β Inhibition Affects Singing Behavior and Neurogenesis in Adult Songbirds. Brain Behav Evol. 2015 DOI: 10.1159/000382029

    Education:
    Weizmann Institute of Science, Rehovot, Israel



  • Seungwoo Yoo
  • Seungwoo Yoo, Ph.D., Postdoctoral Fellow
    yoos@health.fau.edu

    Publications:
    Functional double dissociation within the entorhinal cortex for visual scene-dependent choice behavior, Yoo SW and Lee I, 2017, Elife
    https://www.ncbi.nlm.nih.gov/pubmed/28492367

    Education:
    Seoul National University



  • Seungwoo Yoo
  • Hyewon Woo, M.D.
    fau_hwoo@fau.edu

    Publications:
    H Woo, JM Ko, CH Shin, SW Yang (2016) Two cases of Antley-Bixler Syndrome caused by mutations in different genes, FGFR2 and POR. Journal of Genetic Medicine
    H Woo, BC Lim, HM Kim, H Hwang, JH Chae, KJ Kim (2016) Clinical Characteristics and Treatment Response of Juvenile Dermatomyositis. Korean Child Neurology

    Education:
    2013-2017 Seoul National University Children’s Hospital, Department of Pediatics, Resident
    2012-2013 Seoul National University Hospital, Internship
    2008-2012 Pusan National University, Master’s Degree in Medical Science


 
 

Lab Publications


Voss, M.W., Soto, C., Yoo, S., Sodoma, M., Vivar, C., van Praag, H. Exercise and hippocampal memory systems. Trends in Cognitive Sciences doi.org/10.1016/j.tics.2019.01.006, 2019.

Shen M, Wang F, Li M, Sah N, Stockton ME, Tidei JJ, Gao Y, Korabelnikov T, Kannan S, Vevea JD, Chapman ER, Bhattacharyya A, van Praag H, Zhao X. Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice. Nature Neuroscience doi: 10.1038/s41593-019-0338-y, 2019.

Moon, H.Y., Javadi, S., Stremlau, M., Yoon, K.J., Becker, B., Kang, S.U., Zhao, X., van Praag, H. Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells. Neuropharmacology pii: S0028-3908(18)30830-X, 2018.

Choi, S.H., Bylykbashi, E., Chatila, Z.K., Lee, S.W., Pulli, B., Clemenson, G.D., Kim, E., Rompala, A., Oram, M.K., Asselin, C., Aronson, J., Zhang, C., Miller, S.J., Lesinski, A., Chen, J.W., Kim, D.Y., van Praag, H., Spiegelman, B.M., Gage, F.H., Tanzi, R.E. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science 361(6406). pii: eaan8821, 2018.

Sah, N., Peterson, B.D., Lubejko, S.T., Vivar, C., van Praag, H. Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons. Scientific Reports, 7:10903, 2017.

Moon H.Y., Becke, A., Berron, D., Becker, B., Sah, N., Benoni, G., Janke, E., Lubejko, S.T., Greig, N.H., Mattison, J.A., Duzel, E., van Praag H. Running-induced systemic cathepsin B secretion is associated with memory function. Cell Metabolism 24: 332–340, 2016.

Jongbloets, B.C., Lemstra, S., Schellino, R., Broekhoven, M.H., Hellemons, A.J., Mao, T., Giacobini, P., van Praag, H., De Marchis, S., Ramakers, G.M., Pasterkamp, R.J. Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nature Communications, ncomms 14666, doi: 10.1038, 2017.

Mohammad, H., Marchisella, F., Ortega-Martinez , S., Hollos P., Eerola, K., Komulainen, E., Kulesskaya, N., Freemantle, E., Fagerholm, V., Savantous, E., Rauvala , H., Peterson, B.D., van Praag, H., Coffey, E. JNK1 controls adult hippocampal neurogenesis and imposes cell autonomous control of anxiety behaviour from the neurogenic niche. Molecular Psychiatry, doi:10.1038/mp.2016.203, 2016.

Vivar, C., Peterson, B.D., van Praag, H. Running rewires the neuronal network of adult-born granule cells. NeuroImage, 131:29-41, 2016.

 
 

CONTACT US

Henriette van Praag    |    FAU Brain Institute    |    5353 Parkside Drive, MC-17    |    Jupiter, FL33458
hvanpraag@health.fau.edu    |    vanPraagLab@fau.edu


 
 
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our locations:

FAU Brain Institute Jupiter campus
Room 107, MC-17
5353 Parkside Drive, Jupiter, FL 33458
Phone: 561.799.8100   |   Fax: 561.799.8156

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FAU Brain Institute Boca Raton campus
Room 103A, SE-43
777 Glades Road, Boca Raton, FL 33431
Phone: 561.297.4989

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